STAGING SYSTEMS FOR CHRONIC LYMPHOCYTIC LEUKEMIA



Modified Rai System
Rai et al, Blood 1975;46:219
 
Level of risk Stage Description
Low 0 Lymphocytosis only (blood and marrow)
  I Lymphocytosis plus enlarged lymph nodes
Intermediate II Lymphocytosis plus enlarged spleen and/or liver, ± lymphocytosis
  III Lymphocytosis plus anemia (Hgb <11 g), ± enlarged nodes, spleen or liver
High IV Lymphocytosis plus thrombocytopenia (plts < 100K), ± anemia, enlarged nodes, spleen or liver



Binet System
Binet et al, Cancer 1981;48:198
 
Stage Description
A Lymphocytosis with two or less node-bearing areas enlarged
B Lymphocytosis with more than two node-bearing areas enlarged
C Anemia (hemoglobin < 10 g) or thrombocytopenia (plts < 100K)